BuyangHuanwuDecoction (BHD) is a well-known Chinese herbal prescription for ischemic stroke.The objective of this systematic\r\nreview and meta-analysis is to provide the current evidence for neuroprotective effects of BHD and its possible mechanisms in\r\nanimal models of focal ischemia. A systematic literature search, through October 2012, was performed using six databases. The\r\noutcome measures assessed were infarct size and/or neurological score. Fifty-six studies with 1270 animals that met the inclusion\r\ncriteria were identified. The median score for methodological quality was 3 with a range of 2 to 6. Compared with vehicle or no\r\ntreatment controls, BHD gave a 37% improvement in outcome for all doses ranging from 1.0 g/kg to 60 g/kg at each time point that\r\nBHDwas administered (P < 0.01). Efficacy was higher in mousemodels that utilized suture occlusion and temporary ischemia.The\r\nneuroprotective effects of BHDare involved inmultiplemechanisms and act uponmultiple cell types. In conclusion, BHDpossesses\r\nsubstantial neuroprotective effects in experimental stroke probably as a result of the multitarget therapy strategy typically utilized\r\nin traditional Chinese medicine. Future research should examine the presence of possible experimental bias and an in-depth study\r\nof herbal compound preparations
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